Lung abscess by <i>Fusobacterium nucleatum</i> and <i>Streptococcus</i> spp. co-infection by mNGS: A case series

Abstract A lung abscess is a necrotizing infection caused by microbiomes that lead to the loss of healthy tissue. The routine culture waste time and yields false-negative results, clinicians could only choose empiric therapy or use broad‐spectrum antibiotics, which significantly contribute problem resistance aggravate condition. We report three patients with routine-culture-negative abscess. presenting symptoms included fever, cough, dyspnea, chest pain, computed tomography scan revealed lesion in lungs. bronchoalveolar lavage fluid pleural were tested for pathogens using metagenome next-generation sequencing (mNGS), results Fusobacterium nucleatum Streptococcus spp. ( S. constellatus , intermedius ) as most represented microbial pathogens. Our data demonstrated mNGS be promising alternative diagnostic tool pathogen detection, lists indicate it will important focus on genus rather than dominant terms co-infection determined shotgun mNGS.